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RO 2443
CAS No. 1416663-79-0
RO 2443( RO2443 )
Catalog No. M11736 CAS No. 1416663-79-0
RO 2443 is a potent, dual MDM2/MDMX antagonist that inhibits both MDM2 (IC50=33 nM) and MDMX (IC50=41 nM) binding to p53.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameRO 2443
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NoteResearch use only, not for human use.
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Brief DescriptionRO 2443 is a potent, dual MDM2/MDMX antagonist that inhibits both MDM2 (IC50=33 nM) and MDMX (IC50=41 nM) binding to p53.
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DescriptionRO 2443 is a potent, dual MDM2/MDMX antagonist that inhibits both MDM2 (IC50=33 nM) and MDMX (IC50=41 nM) binding to p53, but poor water solubility does not allow for a meaningful assessment of its cellular activity.
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In Vitro——
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In Vivo——
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SynonymsRO2443
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMDM2-p53
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Research Area——
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Indication——
Chemical Information
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CAS Number1416663-79-0
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Formula Weight401.798
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Molecular FormulaC20H14ClF2N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name2,4-Imidazolidinedione, 5-[(6-chloro-7-methyl-1H-indol-3-yl)methylene]-3-[(3,4-difluorophenyl)methyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Graves B, et al. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11788-93.
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